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RESIST-TB Webinar - Shared screen with speaker view
David Holtzman
35:00
Thank you Aung Aung for your presentation - Can you clarify how many of the children experiencing visual hallucinations or night terrors were receiving both delamanid and cycloserine/terizodone? Any attempts to reintroduce DLM and not Cs or vice versa?
Charlotte Colvin USAID
37:03
Thank you so much Dr. Aung - great presentation. Can you clarify what TB diagnostic testing and drug sensitivity testing was done on the cohort of children? I think you mentioned X-ray, clinical evaluation and smear - I was wondering about additional tests. Thank you.
Nomita
38:37
no sound
Gaƫl Claquin (Mozambique)
42:20
Can you recall what PICC stands for ?
Alex Schmidt
42:46
peripherally inserted central catheter
yara abo
43:05
Peripherally Inserted Central Catheter
Animesh Sinha
51:50
with the new WHO rapid communication on DR-TB treatment, should we now explore the use of these 6 month regimens in children? I think children should also benefit from better and shorter DR-TB regimens.
Nathalie Lachenal
01:04:53
Regarding the question on hallucinations in children - all cases we observed ww were exposed to Dlm, 65% were also exposed to Cs/Trd. Dlm dechallenge was positive in all but 1 case (AE disappeared when Dlm was stopped); Dlm rechallenge was positive in 6 cases (AE reappeared when Dlm resumed); Cs/Trd was additionally suspected and permanently withdrawn when not tolerated. The hallucinations caused by Dlm were fully reversible.
Aung Aung - MSF
01:08:10
Thanks Nathalie for the first question. For the diagnostic testing for children - apart from clinical evaluation and X-rays, we do TST, sputum - induction for child who cannot produce, and culture and DST. We also did an operational research on stool detection of MTB with GeneXpert Ultra which we are doing analysis of the result.
Aparna Iyer-MSF india
01:08:29
9 month regimen for MDR looks good but regimen for FQ R and BDQ resistant with E Z seems weak as most such cases would already be resistant to E Z . can imipenem/meropenem be included?
Carole Mitnick
01:09:42
Thanks, everyone. Tony, the Bdq dosing is 3xweek (after loading) in children, as in adults, right? If so, has there been any empirical work (or simulations, as for adults) about a daily dosing option for children?
Carole Mitnick
01:09:55
And, Aung, following up on Charlotte's question: can you also remind us of the screening part of the algorithm (i.e., was xray performed in all contacts or only those with symptoms)? How did you manage the expertise required to read xrays in kids?
Charlotte Colvin USAID
01:10:58
Thank you Dr. Aung, and looking forward to hearing more about the OR on stool diagnosis when you have results to share.
Carole Mitnick
01:11:08
per Tony's comment about the limited comparative data between pretomanid and delamanid. This has been recently summarized: Delamanid or pretomanid? A Solomonic judgement!J Antimicrob Chemother. 2022 Mar 31;77(4):880-902. doi: 10.1093/jac/dkab505.
Hemant Bogati
01:11:11
TST in Tajikstan presentation was performed for what purpose ? Thanks .
Miriam Arago
01:11:35
We saw few nocturnal terrors in Mumbai but all improved after stoping Cs, we did not need to stop Dlm
Nathalie Lachenal
01:13:12
Anecdotally, also taking Dlm with meals seems to help
Charlotte Colvin USAID
01:16:19
Many thanks to all the presenters - this was a great webinar.
abdul ghafoor
01:17:04
Very informative indeed. Thank you
David Holtzman
01:20:10
@Nathalie - that is an interesting anecdote about taking with meal as food increases absorption of DLM two-fold (fatty foods even more) so one would posit that psych AEs might be increased with higher blood levels.Thank you presenters! Excellent work
Aparna Iyer-MSF india
01:21:12
in India now its suggested to do IGRA and BaselineXRay for asymptomatic contacts, AI options are also being explored
Aparna Iyer-MSF india
01:21:20
thanks a lot to all for this wonderful session
Carole Mitnick
01:21:23
excellent presentations and full webinar. thanks, everyone!
Seraphine Kaminsa
01:21:33
Thank you for very informative session!
Tiziana Masini (WHO/GTB)
01:21:34
excellent presentations, thanks a lot, everyone!
Aparna Iyer-MSF india
01:21:39
thanks dr.aung aung, dr,vijay, dr.cathy. Robert:-)
Adrianna Baker
01:21:41
Thank you everyone! Wonderful webinar!
Mabel
01:21:43
thanks
Nino Lomtadze
01:21:44
Thank you for the very interesting presentations
abdul ghafoor
01:21:47
Thank you for the webinar
punjab-med
01:21:48
Thanks